Endotoxins in the prostatic secretions of chronic prostatitis patients.
نویسندگان
چکیده
AIM To evaluate the clinical significance of the quantitative determinations of endotoxins in the expressed prostatic secretions (EPS) of chronic prostatitis (CP) patients. METHODS The EPS of 45 patients with CP and 15 normal volunteers were obtained for microscopic examination, bacterial culture and endotoxin determination. The level of endotoxins was determined by the Limulus-amebocyte-lysate test with chromogenic substrate. RESULTS Patients with CP had higher mean levels of endotoxins in EPS than normal volunteers [52.06 +/- 32.83 EU/L vs. 4.77 +/- 4.14 EU/L (P <0.05)]. The levels of endotoxins in CP type II, type IIIa and type IIIb were 68.62 +/- 34.78 EU/L, 45.30 +/- 23.33 EU/L and 15.83 +/- 5.31 EU/L, respectively [type II vs. type IIIa (P >0.05), type IIIb vs. normal controls (P <0.05), type II/type IIIa vs. normal controls P >0.05)]. CONCLUSION CP patients have elevated levels of endotoxins in the EPS, which suggests that inflammation is a feature of this disease. EPS endotoxin determination is not only helpful in diagnostic confirmation, but also in evaluating the response to treatment in CP patients.
منابع مشابه
Endotoxins in the prostatic secretions of chronic prostatitis patients: a need for further biomarkers through the use of proteomics.
متن کامل
A method for recognising non-bacterial prostatitis: preliminary observations.
Chronic non-bacterial prostatitis is a difficult condition to diagnose accurately either by symptoms and signs or by investigations. Four groups of patients were assessed for the number of leucocytes and the presence of pathogens in expressed prostatic secretions before and after treatment with co-trimoxazole two tablets twice daily for three months. The pretreatment findings suggest that the u...
متن کاملRecent Developments in Chronic Prostatitis and Pelvic Pain Syndrome
Chronic prostatitis or chronic pelvic pain syndrome (CP/CPPS) is a versatile, clinical condition, which poses challenges for both patients and clinicians. The aim of this review is to survey the literature for recent developments in the etiology, diagnosis and treatment of CP/CPPS. There are many theories regarding the development of CP/CPPS but they require further investigation. To check for ...
متن کاملCryptic bacterial infection in chronic prostatitis: diagnostic and therapeutic implications.
Chronic idiopathic prostatitis, sometimes called prostatodynia or abacterial prostatitis, is a commonly diagnosed and poorly treated urological syndrome. Clinically, this condition frustrates the patient and physician due to its chronicity and resistance to therapy. Recent studies suggest that the etiology of chronic idiopathic prostatitis may be of bacterial origin. Three types of provocative ...
متن کاملProstatitis.
The laboratory diagnosis of acute bacterial prostatitis is straightforward and easily accomplished in clinical laboratories. Chronic bacterial prostatitis, and especially chronic idiopathic prostatitis (most often referred to as abacterial prostatitis), presents a real challenge to the clinician and clinical microbiologist. Clinically, the diagnosis of chronic idiopathic prostatitis is differen...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Asian journal of andrology
دوره 7 1 شماره
صفحات -
تاریخ انتشار 2005